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来自真菌Irpex laceratus的新烯三烯

Chen Chen^1,2, Linjie Wei^1,2, Yunfei Yuan²

¹Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.

Chemistry & biodiversity

|June 13, 2025

概括

研究人员从真菌Irpex laceratus中分离出了六种新的squalene三烯,即irpelacerins A-F. 一些化合物表现出阻碍脂多糖诱导的氧化生产的抑制活性.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
药理学药理学是指药理学的学科.

背景情况:

内生菌,如Irpex laceratus,是新型生物活性化合物的丰富来源.
Casuarina equisetifolia L.是一种药用植物,众所周知是各种内菌微生物的宿主.
包括斯卡烯和拉诺斯坦衍生物在内的三烯酸经常表现出显著的生物活性.

研究的目的:

从内生菌菌Irpex laceratus中分离和鉴定新的烯三烯.
评估分离化合物的生物活性,特别是它们的抗炎潜力.

主要方法:

固体发酵的Irpex laceratus内菌的固体发酵. 这是一个很好的方法.
使用色谱技术分离和净化化合物.
通过广泛的NMR光谱数据和高分辨率电子喷雾电离质谱法来阐明结构.
通过抑制氧化产生的抗炎活性进行生物评估.

主要成果:

鉴定出了6种新的非循环或单循环烯三烯,称为irpelacerins A-F (1-6).
还分离了三种已知的lanostane三基 (7-9).
化合物3,6,8和9表现出显著的抑制活性,对脂聚糖 (LPS) 诱导的氧化 (NO) 生产.
这些活性化合物的IC50值在32.5至76.8μM之间.

结论:

植物内菌Irpex laceratus含有结构独特的烯三烯.
伊尔佩拉塞林A-F代表了一类新的链状三类.
化合物3,6,8和9通过抑制NO生产具有抗炎性质,这表明潜在的治疗应用.

关键词:

在Casuarina equisetifolia中使用.伊尔佩克斯 (Irpex laceratus) 是一个的动物.它具有抗炎活性,具有抗炎活性.二次代谢产物二次代谢产物三烯酸是三烯酸的一种.

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