微注射器用于在胃肠道中控制的跨界药物输送
Joshua A Levy1,2,3, Michael A Straker2,3,4, Justin M Stine2
1Department of Materials Science and Engineering, University of Maryland, College Park, Maryland 20742, United States.
ACS applied materials & interfaces
|June 13, 2025
概括
研究人员开发了新的可摄入注射器,用于控制胃肠道药物输送. 这项技术使可调节的释放配置文件从几秒到几个月,从而改善患者的治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 胃肠道治疗药物 胃肠道治疗药物
背景情况:
- 胃肠道 (GI) 管是药物输送的关键位置,因为它的可访问性和患者的偏好.
- 现有的可摄入器件可以促进向的输送,但缺乏在肠道内控制释放的能力.
- 从胃肠道器件中控制药物释放仍然是制药科学的欠发达领域.
研究的目的:
- 开发和演示一种多功能半静止注射技术,用于在肠道内调节药物输送.
- 创建一种能够在长时间内精确,可控地释放治疗剂的新系统.
- 建立一个框架,用于胃肠道药物输送的先进制造技术.
主要方法:
- 开发混合3D打印的水库和微针结构,具有可变的材料和几何性质.
- 整合了先前开发的可吞激活技术,用于将设备部署到肠道组织中.
- 对注射系统进行测试,以通过可调节的释放动力学通过粘膜屏障进行受控的剂量注射.
主要成果:
- 已证明可调节的药物输送量超过5μL.
- 实现药物释放半衰期从4秒到118天.
- 验证了注射器在肠道组织中有效部署和剂量的能力.
结论:
- 开发的半静止注射技术为控制的胃肠道药物输送提供了一个多功能平台.
- 混合3D打印的微针注射器使量身定制的剂量和延长释放配置文件成为可能.
- 这种先进的制造方法为加强对胃肠道药物输送的控制提供了一个框架.
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