患有急性损伤需要持续置换治疗的患者的急性骨肌肉衰竭:一项前性多中心研究
Kirby P Mayer1, J Pedro Teixeira2, Felipe González-Seguel3
1Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Journal of critical care
|June 13, 2025
概括
患有急性损伤 (AKI) 的重症患者需要持续置换疗法 (CKRT),在治疗的第一周内经历了显著的肌肉损耗. 大比例的幸存者在医院出院后出现了重症监护室相关的虚弱 (ICU-AW).
科学领域:
- 关键护理医学 关键护理医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 物理疗法物理治疗
背景情况:
- 急性损伤 (AKI) 在重症患者中很常见.
- 持续置换疗法 (CKRT) 常常是AKI管理所需的.
- CKRT对肌肉健康和ICU相关虚弱 (ICU-AW) 的影响尚未得到充分证实.
研究的目的:
- 为了前性地评估肌肉质量和质量变化在重症患者成年人AKI接受CKRT.
- 在这个患者群体中确定医院出院时的ICU相关虚弱 (ICU-AW) 的发生率.
主要方法:
- 在两个学术医院进行前性观察研究.
- 招募了患有需要CKRT的AKI的重病成年人.
- 在CKRT的第一周,使用超声波 (US) 评估直骨肌肉质量和质量.
- 在医院出院时评估了ICU-AW,身体功能和脆弱性.
主要成果:
- 招募了23名患者;中位数年龄56岁,BMI29kg/m2,查尔森并发症指数3.
- 在CKRT的第一周内发生了显著的肌肉损耗:直骨肌肉厚度减少了10%,横截面积减少了19%,回声强度 (质量) 增加了14%.
- 67%的幸存者 (10/15) 在出院时符合ICU-AW的标准.
结论:
- 需要CKRT的AKI患者在治疗的早期经历了大量的肌肉损耗.
- 在接受CKRT治疗的AKI幸存者中观察到与ICU相关的高发弱率.
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