改变的神经振荡与在服用D-cycloserine后改善精神分裂症患者的工作记忆性能有关
Emma Mirhashemi1, Peter Bachman2, Giri Krishnan3
1Department of Psychology, University of Washington, Seattle, Seattle, WA, United States.
Schizophrenia research
|June 13, 2025
概括
精神分裂症患者服用D-环素 (一种N-甲基-d-酸盐谷氨酸受体激动剂) 显示工作记忆得到改善. 这与玛,和α脑振荡的变化有关,这表明了潜在的认知增强机制.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 认知缺陷,特别是工作记忆受损,是精神分裂症的标志.
- 假设这些缺陷源于N-甲基-d-阿斯巴达酸谷氨酸受体 (NMDAR) 的低功能.
- 工作记忆依赖于神经振荡,包括马,塔和α波段,这些波段在精神分裂症中受到影响.
研究的目的:
- 研究与D-环素 (DCS) 治疗的精神分裂症患者工作记忆改善的基础的神经振荡机制.
- 为了检查与安慰剂相比,在接受DCS的患者中,玛,塔和α振荡的变化.
主要方法:
- 分析之前一项双盲,随机,安慰剂对照研究的脑电图 (EEG) 数据.
- 在工作记忆任务中,用D-环素 (SZ-DCS) 和安慰剂 (SZ-安慰剂) 治疗的精神分裂患者之间的神经振荡 (,甲,α) 的比较.
主要成果:
- SZ-DCS患者表现出前和后区域的工作记忆相关的马功率降低.
- 在SZ-DCS患者的内存负载中观察到降低的前额 teta 功率.
- 在SZ-DCS患者中,在对照条件下发现左半球α功率增加,但在工作记忆任务中没有.
结论:
- 使用D-环素增强NMDAR信号可能会改善精神分裂症患者的工作记忆.
- 观测到的玛和塔振荡的变化表明,支持工作记忆需求的效率提高了.
- 阿尔法振荡的调制可能有助于改善准备性注意力过程.
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