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和多基基物质与不明原因的复发性自发性流产之间的关联:中国的一项病例对照研究

Qianxi Cheng¹, Chunxian Lv¹, Yawei Li¹

¹China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.

Ecotoxicology and environmental safety

|June 13, 2025

概括

母亲暴露在某些和多基物质 (PFAS) 中,特别是PFBA和PFDoDA,与无法解释的复发性自发性流产 (URSA) 的风险增加有关. 这项研究强调了特定的PFAS作为对URSA发展的潜在贡献者.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
分析化学分析化学

背景情况:

和多基基物质 (PFAS) 是广泛存在的环境污染物.
以前的研究表明,PFAS与不良妊娠结果有关.
PFAS和不明原因的复发性自发性流产 (URSA) 之间的特定联系需要进一步调查.

研究的目的:

调查母体血清PFAS暴露与URSA风险之间的关联.
确定可能导致URSA的特定PFAS.
探索多种PFAS对URSA风险的综合影响.

主要方法:

一项涉及110例URSA病例和91例北京对照病例的病例控制研究.
使用超高性能液体染色学-并联质谱法 (UHPLC-MS/MS) 测量母亲血清中的15种PFAS.
使用多重物流回归,加权量子总和 (WQS) 回归,量子g计算 (QGC) 和贝叶斯内核机器回归 (BKMR) 的协会分析.

主要成果:

PFBA,PFDoDA,PFHxS和PFHpS的血清度升高与URSA风险增加有关.
6:2 Cl-PFESA显示与URSA风险降低有显著关联.
确定PFBA和PFDoDA是PFAS对URSA风险混合影响的主要贡献者.

结论:

母体血清PFAS,特别是PFBA和PFDoDA,可能会增加无法解释的复发性自发性流产的风险.
像PFBA和PFDoDA这样的特定PFAS是URSA风险的关键贡献者.
这些发现强调了监测和减轻怀孕期间PFAS暴露的重要性.

关键词:

案例控制研究研究.和多醇基物质是多和多的.无法解释的复发性自发性流产

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