儿童和他们的父母的阻塞性睡眠呼吸暂停的发病率和死亡率:一项受控的国家研究
Poul Jennum1, Nanette Debes2, Rikke Ibsen3
1Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Sleep medicine
|June 13, 2025
概括
患有阻塞性睡眠呼吸暂停 (OSA) 的儿童在诊断前会出现显著的健康问题,死亡率增加. 父母的OSA也显示出强烈的家庭联系,表明儿童OSA的共同风险因素.
科学领域:
- 儿科肺病学 儿科肺病学
- 睡眠医学 睡眠医学
- 遗传学和家庭研究.
背景情况:
- 儿童阻塞性睡眠呼吸暂停 (cOSA) 与严重的健康问题和死亡率有关.
- 关于COSA儿童及其父母诊断前健康问题的数据有限.
研究的目的:
- 调查被诊断患有OSA的儿童的诊断前发病率和死亡率.
- 检查父母的并发症和父母的OSA (pOSA) 对cOSA的影响.
主要方法:
- 从丹麦国家患者登记处确定了一组2821名被诊断患有OSA的儿童 (3-19岁).
- 9901名对照人群根据年龄,性别和社会经济地位进行了匹配.
- 分析了诊断前的发病率,死亡率和父母的OSA.
主要成果:
- 患有cOSA的儿童在诊断前3年内,在所有世卫组织疾病类别中表现出明显更高的发病率,特别是在内分泌,神经和呼吸系统中.
- 与对照组 (2/10,000) 相比,cOSA患者的五年死亡率 (18/10,000) 显著高于对照组 (2/10,000),危险率为3.8.
- 父母的OSA与他们的孩子有着相似的并发症模式,并观察到强烈的家族关联 (OR为父亲2.3,母亲8.7).
结论:
- 患有OSA的儿童面临着严重的诊断前健康负担和增加的死亡率.
- OSA显示出强烈的家族风险,父母和孩子之间共享的并发症.
- 这些发现突显了cOSA的系统影响和家族病史的重要性.
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