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用F-AlF-NOTA-FAPI-04正子发射断层扫描/计算机断层扫描 (PET/CT) 进行胰腺癌成像:分布模式和治疗影响

C Wang¹, Z Zhu², L Xu²

¹Shandong University Cancer Center, Cheeloo College of Medicine, Shandong University, Jinan, 250117, Shandong, China; Department of Radiation Oncology, Affiliated Cancer Hospital of Shandong First Medical University, 440Jiyan Road, Huaiyin District, Jinan, 250000, China.

Clinical radiology

|June 13, 2025

概括

[¹⁸F]F-AlF-NOTA-FAPI-04 PET/CT对胰腺癌具有很高的特异性,特别是在头部/部瘤中. 在其他癌症中对非特异性胰腺吸收需要仔细解释,以确保准确的诊断.

科学领域:

核医学就是核医学.
在瘤学瘤学.
放射化学放射化学是指辐射化学.

背景情况:

纤维细胞激活蛋白 (FAP) 在与癌症相关的纤维细胞中高度表达.
[¹⁸F]F-AlF-NOTA-FAPI-04是一种针对FAP的新型正子发射断层扫描 (PET) 追踪器.
准确诊断胰腺癌对于及时治疗至关重要.

研究的目的:

为了评估[¹⁸F]F-AlF-NOTA-FAPI-04 PET/CT在胰腺癌中的诊断性能.
为了比较胰腺和非胰腺瘤之间针对FAP的PET/CT吸收模式.
调查影响胰腺生理吸收的因素.

主要方法:

对103名以前未接受过治疗的癌症患者 (36名胰腺癌,67名非胰腺癌患者) 的前性研究.
从[¹⁸F]F-AlF-NOTA-FAPI-04 PET/CT扫描中分析了代谢性瘤体积 (MTV),标准化吸收值 (SUV) 和病变FAP总表达 (TLF).
统计分析包括等级回归和独立的t测试.

主要成果:

与非胰腺瘤相比,胰腺癌的SUVmax,SUVmean和TLF显著更高 (P<0.001).
胰腺头部/部区域的瘤的SUV平均值高于身体/尾部病变 (P=0.016).
TLF与瘤大小和阶段正相关 (P=0.027);在一些肝细胞癌病例中观察到轻度胰腺吸收.

结论:

[¹⁸F]F-AlF-NOTA-FAPI-04 PET/CT对胰腺管腺癌具有很高的特异性,特别是在头部/部瘤中.
在非胰腺恶性瘤中,非特异性胰腺吸收需要仔细解释,以防止误诊.
这种追踪器显示了在胰腺癌检测中改善诊断准确性的前景.

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