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Updated: Jun 16, 2025

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
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骨髓状单细胞驱动CAR-T细胞在侵袭性B细胞淋巴瘤中的抗性

David Stahl1, Philipp Gödel2, Hyatt Balke-Want3

  • 1Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany; Cancer Research Center Cologne Essen (CCCE), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Mildred Scheel School of Oncology Aachen Bonn Cologne Düsseldorf (MSSO ABCD), Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.

Cancer cell
|June 13, 2025
PubMed
概括

攻击性B-NHL中CAR-T疗法耐药性与淋巴瘤相关的骨髓单细胞细胞有关. 用CAR-T细胞阻断CSF1R协同改善了小鼠模型的结果,提供了一个新的治疗策略.

关键词:
在CAR-T细胞中.在CSF1R中,CSF1R是最重要的.一个积极的B-NHL.淋巴瘤瘤微环境是一个微环境.骨髓状细胞是骨髓状细胞的组成部分.

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