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血管直径决定了人体中腹腔和动脉中可溶性酸环酸激活的敏感性

Lubomir T Lubomirov¹, Simon Jasinski-Bergner², Kangbo Li³

¹Institute of Physiology, Brandenburg Medical School Theodor Fontane, Fehrbelliner Straße 38, 16816 Neuruppin, Germany; Center of Physiology, University of Cologne, Robert-Koch-Strasse 39, 50931 Cologne, Germany; Department of Physiology, and Pathophysiology, Department of Medicine, Research and Educational Center (ZAFB), Healthcare Faculty, University of Witten/Herdecke, Witten, Germany; Vascular Biology Research Group (RenEVA), Research Institute, Medical University-Varna, Varna, Bulgaria.

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概括

人类小动脉在可溶性酸环酸酶 (sGC) 激活时表现出比大动脉更大的血管扩张. 这种反应独立于血管的年龄或位置,强调了血管直径在sGC/蛋白激酶G (PKG) 路径信号传导中的重要性.

科学领域:

心血管生物学心血管生物学
血管生理学血管生理学
药理学药理学是指药理学的学科.

背景情况:

可溶性酸环酶 (sGC) /蛋白激酶G (PKG) 途径在调节血管度方面发挥着至关重要的作用.
了解影响sGC激活器功效的因素对于开发针对心血管疾病的向疗法至关重要.

研究的目的:

为了确定动脉血管扩张是否响应sGC/PKG通路激活,随着年龄,血管位置或人类的直径而变化.
阐明了人类动脉中sGC激活剂诱导的血管扩张背后的分子机制.

主要方法:

电线肌图被用来评估从年轻和老老的小鼠和人类患者中腹和内动脉的血管扩张.
血管被用酸 (SNP) 或sGC激活剂cinaciguat刺激.
西方涂抹测量了MLC20-S19和MYPT1 (T853,S668) 的酸化,以评估分子信号.

主要成果:

在小鼠中,血管扩张在内动脉比中腔动脉低,没有年龄依赖.
人体中腔和内动脉表现出与SNP和cinaciguat相似的血管扩张.
较小的人类动脉 (<700微米) 与较大的血管 (>700微米) 相比,显示出更强的cinaciguat诱导的血管扩张.
奇纳西瓜特在较小的人体血管中增加了PKG依赖的MYPT1-S668酸化,但在较大的血管中没有增加.

结论:

人体内和中腔动脉的血管扩张与sGC激活器相似,与小鼠模型不同.
动脉直径是人类对sGC激活反应的关键决定因素,较小的血管更敏感.
根据血管大小,MLC20-S19酸化的程度似乎不会影响对sGC激活的差异反应.

关键词:

动脉动脉中的动脉人类人类人类人类人类脏 - 脏 - 脏中间建筑 (Mesentery) 是一个中间建筑.可溶性瓜尼酸环酸酶是什么?

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