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先进的生物材料用于针对性地向固体瘤输送免疫检查点抑制剂

Emily M Henrich¹, Kevin J McHugh²

¹Department of Bioengineering, Rice University, USA.

Journal of controlled release : official journal of the Controlled Release Society

|June 13, 2025

概括

使用工程生物材料的免疫检查点抑制剂 (ICI) 的局部递送可以提高癌症治疗的疗效,同时减少副作用. 这种方法旨在改善对当前疗法耐药的患者的治疗结果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物材料科学生物材料科学

背景情况:

免疫检查点抑制剂 (ICI) 通过利用免疫系统,改变了癌症治疗.
然而,ICI面临着一些挑战,包括某些患者的无效性和显著的免疫相关不良事件 (irAEs).
目前的施用方法导致迅速的全身分布,限制治疗潜力和增加毒性.

研究的目的:

审查ICI的先进交付策略,以提高有效性和减少irAEs.
探索工程生物材料在增强当地ICI交付方面的潜力.
确定有前途的策略,以改善ICI交付的临床转化.

主要方法:

对局部ICI管理的临床前和临床研究的审查.
对工程生物材料策略进行分析,以提高药物输送 (例如,改善透,保留,向).
对瘤微环境响应系统和细胞贩运方法的评估.

主要成果:

在临床前模型中,ICI的局部管理显示了潜在的强度增加和毒性降低的潜力.
工程生物材料提供延长药物保留和有效向瘤部位的机制.
策略包括抗体介导向,响应系统和基于细胞的传递.

结论:

工程生物材料在优化本地ICI交付方面具有重大前景.
这些先进的策略有可能克服当前ICI疗法的局限性,提高安全性和有效性.
需要进一步的研究和临床翻译,才能充分发挥这些创新的交付系统的潜力.

关键词:

生物材料是一种生物材料.药物输送是药物输送的过程.免疫检查点抑制剂免疫检查点抑制剂癌症免疫疗法免疫疗法

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