脊髓麻醉后的预防:Ondansetron与Nefopam - - 一个潜在的随机对照试验
Joanna Tohme1, Joan Chehade1, Hicham Abou Zeid1
1Saint-Joseph University, Hôtel-Dieu de France Hospital, Department of Anesthesia and Critical Care, Beirut, Lebanon.
Brazilian journal of anesthesiology (Elsevier)
|June 13, 2025
概括
尼福帕姆有效地预防脊柱后麻醉 (PSAS) 和心血管副作用,比Ondansetron更好. 然而,Ondansetron可以减少恶心和吐,而无需给予疼痛.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 脊柱后麻醉 (PSAS) 是与患者发病率增加相关的常见并发症.
- 目前用于PSAS预防的方法缺乏对Nefopam和Ondansetron进行比较研究.
研究的目的:
- 为了比较Nefopam与Ondansetron在预防PSAS方面的疗效.
- 为了评估相关的副作用,包括低血压,心肌梗塞,恶心和吐.
主要方法:
- 一项前性,随机,双盲,受控试验,涉及150名接受脊髓麻醉的成年患者.
- 患者在麻醉之前接受了8毫克的Ondansetron或20毫克的Nefopam静脉注射.
- 他们监测了发,低血压,胸肌梗塞,恶心,吐,体温和注射部位疼痛.
主要成果:
- 与Ondansetron相比,nefopam显示PSAS的发生率显著降低 (16%与23.9%) 和心血管事件 (低血压,心) 显著降低.
- 昂丹塞特朗显示,恶心和吐的发生率显著降低 (1.3%对12%).
- 尼福帕姆的使用与注射部位疼痛 (45.3%) 的更高率有关.
结论:
- 在PSAS预防方面,nefopam似乎比ondansetron更有效,心血管安全性更好.
- 丹塞在减少恶心和吐方面优越,并且在服用期间更好地耐受.
- 在Nefopam和Ondansetron之间做出选择可能取决于患者的风险因素和预期结果.
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