在全原造血细胞移植后的支气管切除症 - - 一种被诊断不足的并发症
Ophir Freund1, Yitzhac Hadad2, Anne Bergeron3
1The Institute of Pulmonary Medicine, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Respiratory medicine
|June 13, 2025
概括
支气管切除症 (BE) 影响了20%的患者在异性造血细胞移植 (allo-HCT) 后,增加了死亡风险. 这个条件,这个条件.
科学领域:
- 血液学和瘤学研究
- 肺部病理学 肺部病理学
- 移植医学 移植医学
背景情况:
- 支气管切除症 (BE) 在异构后造血细胞移植 (allo-HCT) 后经常与支气管炎消灭症综合征 (BOS) 相联系.
- 关于BE在allo-HCT接受者的流行率和特征的数据有限.
研究的目的:
- 为了确定发病率,临床特征和新发病的症状性支气管炎症 (BE) 的结局,在 allo-HCT.
- 为了确定与BE相关的风险因素和死亡率,在 allo-HCT之后.
主要方法:
- 在2014-2022年期间接受allo-HCT的队列的前性分析.
- 对症状患者的胸部CT扫描进行了BE的审查,比较了移植前和移植后的发现.
- 肺功能测试 (PFTs) 和死亡率在患有和没有BE的患者之间进行了比较.
主要成果:
- 20% (36/182) 符合条件的allo-HCT幸存者开发了新发病的BE.
- 对于BE的独立预测因素包括慢性移植对宿主疾病和较低的基线FEV1.
- BE与死亡风险增加近两倍有关,在符合BOS标准的患者中进一步增加.
结论:
- 支气管切除症是alo-HCT后的一个常见且显著的并发症.
- BE对结果的影响很大,并不能完全由共存的BOS解释.
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