剂量和模式 - 身体活动与更低的痴呆风险有关
Yan Wang1, Fangyu Li1, Shuman Cao1
1Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.
The journal of prevention of Alzheimer's disease
|June 13, 2025
概括
每周达到300分钟以上的中度至强度体力活动 (MVPA),即使是集中体力活动,也会显著降低痴呆风险. 轻度体力活动 (LPA) 也可以帮助减少风险,当MVPA是不够的.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 具体的体育活动量和模式对认知健康的益处尚不清楚.
- 了解大脑健康的最佳体育活动对于公共卫生战略至关重要.
研究的目的:
- 调查不同体力活动量和模式与痴呆风险之间的关联.
- 确定轻度体力活动 (LPA) 是否可以减轻缺乏中度至强度体力活动 (MVPA) 的个体痴呆风险.
主要方法:
- 来自91512名英国生物库参与者 (2006-2024) 的MVPA和LPA加速仪数据的分析.
- 考克斯的比例危险回归模型评估了痴呆症发病率 (所有原因,AD,VaD) 与身体活动水平和模式.
- 分层分析检查了根据年龄,性别和APOE ε4状态的效应;评估了LPA在低MVPA群体中的作用.
主要成果:
- 累积超过300分钟/周的MVPA与痴呆症风险降低有关,不管它是集中 (1-2天) 还是定期.
- 周末MVPA模式显示痴呆的危险比为0.73 (95%CI:0.60-0.89),常规模式显示0.79 (95%CI:0.64-0.98).
- 超过840分钟/周的LPA与那些没有有效的MVPA水平的人中较低的痴呆发病率有关.
结论:
- 超过300分钟/周的MVPA,缩或分布,与痴呆的风险降低有关.
- 较高的轻度体力活动 (LPA) 水平可以部分抵消与低MVPA相关的痴呆风险增加.
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