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性发育患者生育能力差异的差异

Morgane Carre Lecoindre¹, Courtney Finlayson², Philippe Touraine³

¹Department of Pediatric Endocrinology and Metabolism and Adolescent Medicine, Bicêtre Hospital, Le Kremin Bicêtre, France.

Best practice & research. Clinical endocrinology & metabolism

|June 13, 2025

概括

管理性别发育差异 (DSD) 需要个性化生育评估. 生育保存的选择正在不断发展,但患者和提供者对风险和未来可能性的知识差距仍然存在.

科学领域:

内分泌学在内分泌学.
生殖医学生殖医学
遗传学遗传学是一个

背景情况:

性发育差异 (DSD) 的管理正在发展,越来越强调生育能力的保护.
医疗保健提供者和患者之间存在重大知识差距,这些差距涉及DSD中的生育潜力和保存选项.
在DSD中对生育的考虑是复杂的,需要根据诊断,生殖腺状况和年龄进行个性化评估.

研究的目的:

审查当前的知识和在性别发育差异的个体生育管理不断发展的策略.
突出评估生育潜力的复杂性和挑战,并为DSD患者提供保存选择.
讨论DSD管理决策的影响,包括预防性淋巴切除术和遗传咨询,对未来的生育能力.

主要方法:

对当前的研究和临床指南的文献综述关于DSD和生育能力.
在各种DSD条件下分析影响生育潜力的因素.
检查辅助生殖技术 (ART) 和生育保存技术的进展.

主要成果:

在DSD中生育潜力是高度可变的,并且取决于诊断.
在某些DSD疾病中增加淋巴细胞生殖细胞瘤的风险需要仔细考虑淋巴切除术.
潜在的配子可能与个体的性别指定或性别认同不一致,增加了复杂性.
遗传性DSD疾病需要遗传咨询来解决遗传风险.
儿科发病的DSD管理涉及父母的决策,影响对生育保护的同意/同意.

结论:

在DSD中生育管理需要一个多学科的,个性化的方法.
在ART和生育保护方面的进步提供了更好的结果和未来的可能性.
解决知识差距和伦理考虑对于DSD生育管理中最佳的患者护理至关重要.

关键词:

这就是DSD DSD.生育能力生育能力生育能力生育能力保护生育能力保护生育能力遗传咨询遗传咨询遗传咨询发生性生殖的阴茎

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