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相关概念视频

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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相关实验视频

Updated: Jun 16, 2025

Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production
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在小鼠中,二 (2-乙烯基) 甲酸盐通过破坏微生物-肠-海波他拉米-垂体-卵巢轴来降低妊娠率.

Linjie Xu1, Jun Yan2, Tingting Yin2

  • 1Department of Obstetrics, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu, PR China. linjiexu@njmu.edu.cn.

NPJ biofilms and microbiomes
|June 13, 2025
PubMed
概括

暴露于二 (2-乙基) 甲酸盐 (DEHP) 通过破坏肠道微生物群和下丘脑-垂体-卵巢 (HPO) 轴来降低生育能力. 这种可塑剂会损害卵巢功能,并改变关键的激素信号通路,影响生殖健康.

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科学领域:

  • 内分泌学 在内分泌学.
  • 微生物学 微生物学
  • 毒理学 毒理学 毒理学

背景情况:

  • (2-乙基) 甲酸盐 (DEHP) 是一种常见的增塑剂和内分泌干扰剂,与生殖健康风险有关.
  • 下垂体-垂体-卵巢 (HPO) 轴调节生殖功能,对环境暴露很敏感.
  • 肠道微生物组的改变越来越被认为是导致各种健康问题的因素,包括内分泌干扰.

研究的目的:

  • 通过小鼠模型的肠道微生物组破坏,研究DEHP暴露对HPO轴的影响.
  • 阐明DEHP影响生殖功能的特定分子机制.
  • 确定将环境污染物与生殖功能障碍联系起来的新途径.

主要方法:

  • 暴露于DEHP的小鼠.
  • 评估生殖参数,包括怀孕率和卵巢功能.
  • 对HPO轴组件的分析,包括下丘脑星细胞激活和神经调节素1 (NRG1) 表达.
  • 研究肠道微生物群的组成和功能,重点关注与β-葡萄糖酶相关的种类.
  • 测量前列腺素E2 (PGE2) 和性腺激素释放激素 (GnRH) 的水平.

主要成果:

  • 暴露于DEHP显著降低了怀孕率和卵巢功能受损.
  • DEHP激活了下丘脑的星球细胞,并增加了NRG1的表达,导致PGE2和GnRH的升高.
  • DEHP改变了肠道微生物群,破坏了微生物网络的稳定性,并影响了与β-glucuronidase相关的种群,与激素波动相关.
  • 这些变化集体地破坏了HPO轴的平衡,并降低了生育能力.

结论:

  • 肠道微生物组的干扰代表了一种新的机制,DEHP暴露会干扰生殖功能.
  • 由DEHP引起的HPO轴的破坏涉及NRG1介导的信号和肠道微生物群落的变化.
  • 了解这些途径为与甲酸盐暴露相关的生殖健康风险提供了关键的见解.