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Updated: Jun 16, 2025

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通过新的胆固醇合成,ATR促进mTORC1的活性

Naveen Kumar Tangudu1,2, Alexandra N Grumet3, Richard Fang1,2

  • 1Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

EMBO reports
|June 13, 2025
PubMed
概括

ATR 激酶通过调节胆固醇合成来促进mTORC1的活动,将DNA损伤反应和细胞代谢联系起来. 这种途径在正常细胞和癌细胞中都很活跃,特别是当p16减少时.

关键词:
胆固醇 胆固醇 胆固醇兰醇合成酶 兰醇合成酶lysosome 是一个溶解体.代谢过程中的代谢.p16 p16 在这个问题上.

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