鼠母体微生物组修改了蛋白质营养不良对后代神经行为的不良影响
Elena J Coley-O'Rourke1, Gregory R Lum2, Geoffrey N Pronovost2
1Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA. ecoley7@g.ucla.edu.
Nature microbiology
|June 13, 2025
概括
在小鼠中产前蛋白质限制会损害后代的神经行为. 这些影响取决于胎儿发育和母亲生理学,受到母亲微生物群的影响.
科学领域:
- 发育生物学是发展生物学.
- 神经科学是一个神经科学.
- 微生物组研究的研究.
背景情况:
- 儿童蛋白质营养不良会影响生长和神经发育.
- 时间,环境和母亲因素对这些结果的具体影响仍然不清楚.
研究的目的:
- 研究产前蛋白质限制对后代神经行为发育的影响.
- 阐明胎儿发育,母亲生理和母亲微生物组在调解这些影响中的作用.
主要方法:
- 利用小鼠模型,在怀孕期间因母体蛋白质限制而引起的胎儿生长限制.
- 采用交叉培养实验来区分母与新生儿的影响.
- 分析了母亲的肠道微生物组,免疫,牛奶和血清代谢概况.
- 检查了胎儿大脑的转录和代谢概况.
- 为评估干预效应,向母体给予一种代谢物尾酒.
主要成果:
- 蛋白质受限母的成年后代表现出认知和焦虑类行为异常.
- 行为障碍需要胎儿编程和母亲周产期生理条件.
- 孕产妇肠道微生物群多样性减少,孕产妇和胎儿的代谢概况发生变化.
- 在胎儿大脑变化中确定了特定的微生物组依赖的代谢物.
- 用特定代谢物对胎儿发育和产后行为产生差异性的影响.
结论:
- 产前母亲蛋白质营养不良显著影响后代的神经行为轨迹.
- 孕产妇的微生物组和相关的代谢变化在调解这些影响方面发挥着至关重要的作用.
- 胎儿编程和母亲的生理适应都对观察到的神经行为结果至关重要.
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