年龄对肝硬化脆弱性的影响:前性队列研究
Omkolsoum Alhaddad1, Maha Elsabaawy2, Asmaa Abedelhai1
1Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen Elkoom, Menoufia, Egypt.
Clinical and experimental medicine
|June 13, 2025
概括
肝硬化时的脆弱性随着年龄的增长而显著增加,超过90%的70岁以上的患者是脆弱的. 晚年和肝功能障碍都独立预测脆弱性,强调需要更好地评估老年人的脆弱性.
科学领域:
- 老年病的医生 老年病的医生
- 肝病学 肝病学是一种肝病学.
- 临床医学 临床医学
背景情况:
- 脆弱性是肝硬化不良结果的新兴预测因素.
- 老龄化和肝脏疾病严重程度在驾驶脆弱性中的相互作用尚未得到充分理解.
研究的目的:
- 评估年龄对肝硬化患者患病率,严重程度和虚弱预测因素的影响.
主要方法:
- 对460名肝硬化成年人的前性观察性研究.
- 使用临床脆弱度量 (CFS) 评估的脆弱性;患者被分类为脆弱 (CFS > 4) 或非脆弱 (CFS ≤ 4).
- 进行多变量和逻辑回归分析,以确定脆弱性的独立预测因素.
主要成果:
- 随着年龄的增长,虚弱的患病率显著增加,从50-59岁患者的42%增加到70岁以上患者的90%以上.
- 年龄 (β = 0.0636,p < 0.001) 和儿童-皮格评分 (β = 0.7874,p < 0.001) 是脆弱的独立预测因素.
- 每增加一年的年龄都会增加虚弱的风险 (OR = 1.13; 95% CI: 1.09-1.17, p < 0.001).
结论:
- 肝硬化中的脆弱性与年龄有很强的关联,并由肝功能障碍驱动.
- 当前的MELD-Na得分可能无法充分捕捉患者的脆弱性,特别是在老年人中.
- 需要进行长度研究和预康复策略,以减轻脆弱性和改善结果.
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