在晚期泌尿腺癌中维护avelumab:西班牙北部的现实数据 (AVEBLADDER研究)
Marta Sotelo1, Mireia Pelaez2, Laura Basterretxea3
1Hospital Universitario Marqués de Valdecilla and IDIVAL, Santander, Spain.
概括
维护治疗avelumab显著改善了晚期泌尿腺癌患者的存活率后化疗. 现实世界的数据证实了益处,但访问障碍限制了其使用,突出了改善治疗可访问性的必要性.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 尿癌研究 尿癌研究
背景情况:
- 根据JAVELIN 100试验数据,AVELumab维护疗法是晚期泌尿腺癌化疗后的标准护理.
- 有限的现实世界欧洲数据存在关于avelumab的有效性和吸收.
研究的目的:
- 评估阿维卢马布在西班牙局部晚期或转移性尿路细胞癌患者的维持治疗的实际有效性.
- 为了比较在化学疗法后接受阿维卢马布和不接受它的患者之间的整体生存率 (OS) 和无进展生存率 (PFS).
主要方法:
- 在14个西班牙医院进行了回顾性研究 (AVEBLADDER).
- 包括2021年1月至2023年6月期间诊断的患者.
- 对以基化疗治疗的患者的OS和PFS的分析,有或没有维护阿维卢马布.
主要成果:
- 中位数的PFS是11.33个月与avelumab对比6.43个月没有.
- 一年后的生存概率为Avelumab的81.6%,而没有Avelumab的45.6% (p < 0.001).
- 没有报告任何意外的毒性.
结论:
- 现实世界的数据支持在临床试验中显示的avelumab维持治疗的生存益处.
- 诸如获取,报销和认识等障碍限制了阿维卢马布在临床实践中的应用.
- 需要进一步的现实研究来解决治疗差异,并改善获得有效治疗的机会.
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