使用拉索-科克斯回归模型评估皮肤癌患者的预后死亡率:一项回顾性研究
Santosh Chokkakula1, Siomui Chong2,3, Yu-Yen Yang4
1Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute Cheongju, Chungbuk, 28644, South Korea.
Discover oncology
|June 13, 2025
概括
这项关于皮肤癌 (CVC) 的研究发现发生率和存活率的性别差异. 女性心血管疾病患者的整体存活时间较短,突出显示需要进行性别特定的临床评估.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 流行病学 流行病学
背景情况:
- 皮肤癌 (CVC) 的风险因素和预后需要阐明及时干预.
- 了解CVC中的性别差异对于有效管理至关重要.
研究的目的:
- 检查CVC的发病风险和预后因素,重点关注基于性别的差异.
- 确定CVC发展和患者生存的关键预测因素.
主要方法:
- 从SEER数据库 (2004-2015) 中分析了1,125个初级CVC病例.
- 采用了多变量逻辑和考克斯回归,拉索和限制立方支线 (RCS) 模型.
- 卡普兰-梅尔分析评估了性别之间的总生存率 (OS) 差异.
主要成果:
- 瘤发病的独立风险因素包括年龄,性别,种族,婚姻状况,AJCC阶段,联合总结阶段,辐射,手术,瘤大小,化疗和淋巴结干扰.
- 年龄,性别,婚姻状况,AJCC阶段,综合总结阶段和手术是OS的重要预测因素.
- 女性CVC患者的寿命显著比男性更短 (P < 0.05).
- RCS模型揭示了年龄和心血管疾病发病率之间的U形,非线性关系.
结论:
- 在心血管疾病发病风险和死亡率预后因素中存在与性别相关的显著差异.
- 调查结果为医疗保健专业人员在CVC临床评估和干预中提供了宝贵的见解.
- 该研究强调了考虑性别作为CVC患者管理和结果的因素的重要性.
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