相关实验视频

Updated: Jun 16, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

58

颗粒细胞-巨细胞殖民地刺激因子可能会通过影响传统树突细胞功能来促进HLA-B27转基因大鼠脊椎关节炎的发展

Amel Ait Ali Said1,2, Chiara Rizzo1,2, Hendrick Mambu Mambueni1,2

  • 1Université Paris Saclay, Université de Versailles St Quentin en Yvelines, Inserm, Infection et Inflammation, Montigny le Btx INSERM UMR1173, UFR Simone Veil, Versailles-Saint-Quentin University, Inserm, France.

Arthritis research & therapy
|June 13, 2025
PubMed
概括

颗粒细胞巨细胞殖民地刺激因子 (GM-CSF) 通过增强常规树突细胞子集2 (cDC2) 功能,促进脊椎关节炎 (SpA) 中的炎症反应. 然而,cDC1中的HLA-B27表达削弱了它们诱导T细胞增殖的能力,揭示了GM-CSF在SpA病变发生过程中的双重作用.

更多相关视频

Generation and Identification of GM-CSF Derived Alveolar-like Macrophages and Dendritic Cells From Mouse Bone Marrow11:05

Generation and Identification of GM-CSF Derived Alveolar-like Macrophages and Dendritic Cells From Mouse Bone Marrow

Published on: June 25, 2016

18.0K
Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis07:58

Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis

Published on: February 25, 2014

28.4K

相关概念视频

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
963