基线心脏--代谢综合征,其过渡和认知障碍之间的关联:来自CHARLS研究的结果
Yuanyue Zhu1,2, Xuejie Wang3, Kan Wang4,5
1Department of Geriatrics, Ruijin hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Diabetology & metabolic syndrome
|June 13, 2025
概括
心血管-脏-代谢 (CKM) 综合征增加了认知障碍的风险. 更高的CKM阶段和疾病进展会增加这种风险,而改善可能会降低这种风险.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 神经学 神经学
背景情况:
- 心血管-脏-代谢 (CKM) 综合症结合了糖尿病,肥胖,心血管疾病和慢性脏疾病.
- CKM综合征和认知障碍之间的关系尚未得到充分理解.
研究的目的:
- 调查CKM综合征阶段和过渡与认知障碍风险之间的关联.
主要方法:
- 长度观察性研究使用来自中国健康与退休长度研究 (2011-2018) 的数据.
- 参与者被分为5个CKM阶段;过渡被分为改善,稳定或进展.
- 后勤回归分析探索了CKM状态和认知障碍风险之间的关联.
主要成果:
- 与0.0阶段相比,较高的CKM阶段 (1-4) 与认知障碍的几率显著增加有关.
- 与稳定阶段相比,CKM阶段的进展显示认知障碍的风险更高 (aOR 1.61).
- 在CKM阶段的改善表明潜在的降低风险 (aOR 0.44).
结论:
- CKM综合征阶段逐渐与认知障碍风险相关.
- CKM阶段进展会增加认知障碍的风险;阶段逆转可能会降低风险.
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