提高大麻素生物可用性:一个交叉研究,比较一种新型的自我纳米乳化药物输送系统和一种商业油基配方
Vered Hermush1,2, Nisim Mizrahi3, Tal Brodezky3
1Geriatric Wing, Laniado Hospital, Netanya, Israel. vhermush@laniado.org.il.
Journal of cannabis research
|June 13, 2025
概括
与传统油滴相比,delta-9-tetrahydrocannabinol/cannabidiol自乳化 (THC/CBD-SE) 粉末显著提高了大麻素的生物可用性和吸收率. 这种新型的输送系统为改善治疗潜力提供了更快的开始作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
背景情况:
- 像delta-9-tetrahydrocannabinol (THC) 和cannabidiol (CBD) 这样的大麻素的口服生物可用性通常受到广泛的第一通代谢的限制.
- 这种代谢途径减少了大麻素的治疗效果,当口服时.
研究的目的:
- 评估通过一种新型THC/CBD自乳化 (THC/CBD-SE) 粉末提供的大麻素的药理动力学和相对生物利用性.
- 为了比较THC/CBD-SE粉末,一种自我纳米乳化药物输送系统,与标准的基于油的大麻素滴.
主要方法:
- 这是一项交叉研究,涉及14名健康志愿者 (3名男性,11名女性).
- 参与者接受了单次口服剂量8mgTHC和8mgCBD的THC/CBD-SE粉末和基于油的滴滴配方.
- 药物动力学参数,包括最大血度 (Cmax) 和达到Cmax (Tmax) 的时间,通过对30天的洗期进行血液样本分析来评估.
主要成果:
- 与油性滴剂相比,THC/CBD-SE粉末显著增加了THC,11-OH-THC和7-OH-CBD的Cmax.
- 与THC/CBD-SE粉末一起观察到11-OH-THC和7-OH-CBD的Tmax较短,这表明作用的开始更快.
- THC/CBD-SE粉末的相对生物可用性是大麻素的两倍多,吸收率提高,开始迅速,耐受性良好.
结论:
- 与传统的油性滴剂相比,THC/CBD-SE粉末显著提高了大麻素的生物可用性和吸收率.
- 这种自我纳米乳化药物输送系统为口服大麻素的管理提供了一个有前途的方法.
- 改善的药理动力学特征表明,通过THC/CBD-SE粉末提供的大麻素具有更大的治疗潜力.
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