评估和提高使用PDCA与HPLC相结合的儿科输液剂量的准确性:来自中国的质量改进研究
Dan Jiang1,2, Min Cui2, Baoxia Fang3
1Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, China.
Journal of pharmaceutical health care and sciences
|June 13, 2025
概括
实施PDCA循环和HPLC显著提高了儿科输液精度. 这提高了接受静脉注射治疗的年轻患者的药物安全性和有效性.
科学领域:
- 制药科学 制药科学
- 临床药房 临床药房
- 质量管理质量管理
背景情况:
- 准确的静脉注射 (IV) 输液配方对于患者的安全至关重要,特别是在儿科环境中.
- 儿科静脉注射药物准备中的偏差可能会导致由于剂量不正确而导致不良事件.
- 确保精确的药物输送至关重要,以避免在脆弱患者群体中过少或过度使用药物.
研究的目的:
- 评估计划-执行-检查-行动 (PDCA) 周期干预对儿科输液制剂质量的影响.
- 评估在PDCA实施之前和之后的酸盐脱andrographolide succinate (PSDS) 输注的准确性和均性.
主要方法:
- 使用的酸盐脱andrographolide苏酸盐 (PSDS) 已成品输液用于分析.
- 从儿科输液室和临床病房的输液袋中收集药物残留样本.
- 在PDCA干预之前和之后使用高性能液体染色学 (HPLC) 来确定药物含量并评估输液准备的质量.
主要成果:
- 整体,非整体和整体输注的合格率在PDCA干预后显著改善 (P < 0.05).
- 具体合格率从92.95%增加到97.56% (整体),82.68%增加到95.12% (非整体),86.59%增加到96.10% (整体).
- 在儿科输液制剂的准确性和统一性方面显著提高.
结论:
- HPLC和PDCA循环管理的综合方法有效地提高了儿科输液制剂的质量.
- 这一综合战略增强了儿科护理中静脉注射药物的治疗效果.
- 突出了临床药房实践中系统质量改进周期的价值.
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