在50岁及以上的人群中,累积的握力和认知功能和日常运作的纵向变化:来自两个纵向队列研究的证据
Bin Han1, Ziqian Zeng2, Ying Wen3,4
1Experimental Teaching Center of Public Health, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China.
概括
较低的累积握力与更快的认知和功能衰退有关. 保持肌肉力量可能有助于预防神经退行性疾病和残疾.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 肌肉强度,特别是手握强度,是老年人整体健康和功能能力的关键指标.
- 以前的研究表明肌肉力量和认知健康之间存在联系,但对累积力量的纵向数据的探索较少.
研究的目的:
- 调查累积握力与认知功能纵向变化之间的关联.
- 检查手握累积强度与日常功能纵向变化之间的关系.
- 评估与累积的手握强度相关的认知和功能障碍的风险.
主要方法:
- 利用了两项大型比较队列研究的数据:英国长度老龄化研究 (ELSA) 和欧洲健康,老龄化和退休调查 (SHARE).
- 从三次重复测量中计算出累积的握力.
- 采用线性混合回归模型来分析纵向变化和考克斯回归模型来分析损伤风险.
主要成果:
- 在ELSA和SHARE队列中,较低的累积握力与较低的全球认知能力和更快的认知衰退率显著相关.
- 累积握力较低的个体表现出较差的日常功能和功能能力的更快的下降.
- 在具有较低累积手握强度的参与者中观察到患有认知和功能障碍的风险更高.
结论:
- 这些发现表明,累积握力减少是老龄化人口加速认知和功能衰退的预测因素.
- 通过持续炼来维持和提高肌肉力量对于预防神经退行性疾病和功能障碍至关重要.
- 这项研究强调了监测和干预肌肉力量作为健康衰老的可修改因素的重要性.
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