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Updated: Jun 16, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
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ProtPhage:用于菌体病毒蛋白识别和功能注释的深度学习框架.

Yuehua Ou1, Qiyi Chen1, Ningyu Zhong1

  • 1College of Computer Science and Software Engineering, Shenzhen University, No. 3688 Nanhai Avenue, Nanshan District, Shenzhen, Guangdong, 518060, China.

Briefings in bioinformatics
|June 14, 2025
PubMed
概括

ProtPhage 通过使用先进的语言模型和新的损失函数,增强了菌体病毒蛋白的识别. 这提高了对抗生素耐药性策略和菌体生物学研究的预测.

关键词:
不对称的损失失.菌体病毒蛋白质的病毒蛋白质蛋白质语言模型

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相关概念视频

Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
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Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
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