在长期COVID患者中进行亚最大2天心肺运动测试,以评估运动能力和运动后症状恶化
Callum Thomas1, Nik Kudiersky2, Paul Ansdell3
1Biomedical and Clinical Science Research Theme, School of Human Sciences, University of Derby, Derby, UK.
Experimental physiology
|June 14, 2025
概括
在长期COVID中,后炼症状恶化会损害身体功能. 心肺运动测试显示,在第二天的第一通风门上,氧气吸收和工作速度下降,表明生理功能恶化.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 运动生理学 运动生理学
背景情况:
- 长期COVID呈现出复杂的病理和影响日常生活的各种症状.
- 后炼症状恶化 (PESE) 影响了长期COVID患者的很大一部分.
- 长期COVID中运动不耐受性的生理基础尚未得到充分理解.
研究的目的:
- 研究长期COVID患者经历PESE的身体功能受损的生理基础.
- 在长期COVID患者的初始测试后24小时评估心肺运动参数的变化.
主要方法:
- 68名患有PESE的长期COVID患者接受了24小时间隔的两个次最大心肺运动测试 (CPET).
- 工作速度是个性化的,测试测量了氧气吸收,工作速度,氧气脉冲和第一通风门 (VT1) 的潮尾二氧化碳.
主要成果:
- 在VT1时的氧气吸收 (V·O2) 从第一天 (0.73 L/min) 到第二天 (0.68 L/min) 显著下降.
- 与第一天相比,VT1的工作速度和氧气脉冲在第二天也显著下降.
- 潮尾二氧化碳的部分压力在第二天略有但显著下降.
结论:
- 心肺运动检测显示PESE的长期COVID患者的氧气运输和/或利用能力受损.
- 身体功能恶化,特别是在VT1时,在运动后24小时显而易见,这表明炼的有害影响.
- 多个生理系统可能会导致长期COVID中的不耐受性,这需要进一步调查.
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