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Updated: Jul 9, 2026

An In Vitro Organ Culture Model of the Murine Intervertebral Disc
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单核空间转录组测序揭示了鼠标模型中脊椎间盘中明显的刺穿诱导的细胞亚群

Guoyan Liang1, Jing Tan2, Chong Chen1

  • 1Department of Spine Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, P.R. China.

Clinical and translational medicine
|June 14, 2025
PubMed
概括

氧化应激通过应激区启动椎间盘退化 (IVDD),激活特定细胞群,如Lcn2+ AFCs和Col3hi NPCs. 这些细胞有助于NP纤维化,而Pdgfra+细胞具有双重起源.

关键词:
在 LCN2 中, LCN2 是这是PDGFRA.椎间盘退化 椎间盘退化氧化应激是一种氧化应激.单核RNA测序的一个核.空间的文字转录体.

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