细菌细菌BN菌株对M1巨抗病毒反应的影响
Keisuke Tobita1, Manami Sawahata1, Keiichiro Imaizumi2
1Industrial Technology Innovation Center of Ibaraki Prefecture, Higashiibaraki-gun, Ibaraki, Japan.
Cell biochemistry and function
|June 14, 2025
概括
纳托的益生菌Bacillus subtilis BN菌株增强了人类M1巨细胞中的抗病毒和抗炎性细胞因子基因表达. 这表明类似收费的受体通路是其对抗病毒感染的免疫调节效应的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 分子生物学分子生物学
背景情况:
- 在对抗致病微生物感染方面,M1巨细胞至关重要.
- 纳托是一种发酵的大豆食品,传统上以其预防感染的特性而闻名.
- 从纳托分离的Bacillus subtilis BN菌株是已知的肠道健康和免疫调节的益生菌.
研究的目的:
- 研究Bacillus subtilis BN菌株对人类M1巨的抗病毒免疫功能的影响.
- 阐明BN菌株免疫调节效应背后的分子机制.
主要方法:
- 人类M1巨细胞源自THP-1单细胞细胞系.
- 在模仿单链RNA病毒感染的模型中,细胞被用Bacillus subtilis BN菌株治疗,有或没有Resiquimod刺激.
- 进行了细胞因子和关键信号分子的基因表达分析,包括收费类受体通路组件和NFκB.
- 使用NFκB敲除来评估其在BN菌株诱导的细胞因子表达中的作用.
主要成果:
- 细菌细菌BN菌株显著增强了M1巨细胞中抗病毒和抗炎细胞因子的基因表达.
- 该BN菌株促进了基因表达和关键分子的酸化在类似收费的受体信号通路内.
- 击败NFκB降低了某些细胞因子mRNAs的BN菌株诱导表达,表明其参与.
结论:
- 细菌细菌BN菌株对人类M1巨细胞表现出强大的抗病毒和抗炎作用.
- 收费类受体信号通路参与调解BN菌株的免疫调节作用.
- 这些发现支持Bacillus subtilis BN菌株作为增强先天抗病毒免疫力的益生菌的潜力.
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