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Updated: Jun 16, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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在多发性硬化症中进行Rituximab临床试点研究中的药理动力学-药理动力学建模:朝着个性化剂量间隔的方向

Trond Trætteberg Serkland1,2, Silje Skrede1,2, Erik Ingmar Hallin1

  • 1Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.

British journal of clinical pharmacology
|June 14, 2025
PubMed
概括

这项研究开发了多发性硬化症患者里图西马布 (RTX) 的药理动力学-药理动力学 (PKPD) 模型. 该模型描述了患者特定的RTX度和CD19+淋巴细胞计数,有助于个性化剂量策略.

关键词:
在 PKPD 建模中,使用 PKPD 模型.个性化治疗 个性化治疗多发性硬化症多发性硬化症药理动力学是药理动力学的一个方面.药物动力学 药物动力学这就是Rituximab.

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

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