基底细胞腺瘤与S100蛋白质阳性"肌瘤":一种独特的三相唾液腺瘤,其特征是CTNNB1突变
Alena Skálová1,2, Martina Bradová3,4, Jan Laco5
1Department of Pathology, Faculty of Medicine, Sikl's, Charles University, E. Benese 13, 305 99, Plzen, Czech Republic. skalova@biopticka.cz.
Virchows Archiv : an international journal of pathology
|June 14, 2025
概括
基底细胞腺瘤 (BCA) 具有丰富的S100蛋白质阳性层表现出独特的三相分化. 这些瘤在免疫表型和分子上与形腺瘤 (PAs) 截然不同.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 分子生物学分子生物学
背景情况:
- 基底细胞腺瘤 (BCA) 是一种良性唾液腺瘤,具有多样化的生长模式.
- 一个BCA的子集具有丰富的S100蛋白质阳性层,表明与多形腺瘤 (PA) 或混合性质的潜在联系.
研究的目的:
- 为了研究丰富的S100蛋白质阳性流体的BCA的免疫类型和分子特征.
- 为了将这些特征与缺乏S100阳性的肌层和富含肌上皮细胞PA的BCA进行比较.
主要方法:
- 针对S100蛋白,SOX10,PLAG1,HMGA2,p63/p40,细胞激素,EMA,LEF1和β-catenin的免疫组织化学 (IHC) 进行检测.
- 下一代测序 (NGS),用于PLAG1重组的光在位杂交 (FISH) 和甲基化分析.
主要成果:
- 具有S100阳性肌体的BCA在肌体中显示了SOX10阳性,并在肌体/上皮部件中频繁表达LEF1/β-catenin.
- 这些BCA含有CTNNB1突变,与PAS不同,PLAG1重组或融合.
- 具有S100阳性层状体的BCA显示出与PA不同的三相分化模式 (管状,肌皮质,层状).
结论:
- 具有丰富的S100蛋白质阳性层体的BCA代表了BCA的独特的三相子集.
- 这一子集在免疫表型和分子上不同于多形腺瘤.
- 这些发现支持对这些富含S100的BCA进行独特的分类.
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