在患有刺激性肠综合征的患者中增加过敏性鼻炎的患病率和症状严重程度
María Cuende-Estévez1, Hind Hussein1, Fedrica Pia1
1Department of Chronic Diseases and Metabolism (CHROMETA), Center for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
患有刺激性肠综合征 (IBS) 的患者患过敏性鼻炎 (AR) 的风险明显更高. 这种组合会对生活质量产生负面影响,并且可能涉及空气和食物过敏原之间的交叉反应.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 过敏学 过敏学
背景情况:
- 刺激性肠综合征 (IBS) 与呼吸道和过敏性疾病的风险增加有关.
- 过敏性鼻炎 (AR) 和IBS之间的联系尚不清楚.
- 调查IBS患者的呼吸道问题和潜在的抗原交叉活性至关重要.
研究的目的:
- 了解IBS患者的呼吸道并发症.
- 评估IBS和AR患者的空气和饮食抗原交叉反应性.
主要方法:
- 287名参与者 (54名健康患者,232名IBS患者) 填写了问卷.
- 评估上呼吸道症状严重程度和AR患病率.
- 用于IBS诊断的罗马四号标准.
主要成果:
- 与对照组相比,IBS患者的AR风险高出三倍.
- 患有AR的IBS患者报告睡眠,情绪和满意度较差.
- 47%的IBS+AR患者经历了IBS症状,原因是食物模仿的空气过敏原.
结论:
- 在IBS患者中,AR的发病率较高,生活质量恶化.
- 有证据表明,IBS+AR患者的空气过敏原和食物抗原之间存在交叉反应.
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