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炎症性关节疾病中的AA氨基粉症:系统性审查

Binta Savadogo¹, Hanna Fahed¹, Jérémie Sellam²

¹Rheumatology Department, Sorbonne University-APHP, Pitié-Salpêtrière Hospital, Paris, France.

Seminars in arthritis and rheumatism

|June 14, 2025

概括

与炎症性关节疾病 (IJD) 相关的AA氨基粉症 (AAA) 似乎正在减少,特别是在2010年之后. 生物疗法可能是导致AAA患病率下降和生物标志物改善的原因.

科学领域:

类风湿病学类风湿病学
腎臟病學 (nephrology) 是一種醫學.
免疫学免疫学免疫学

背景情况:

粉样粉症 (AAA) 是慢性炎症的一种并发症.
预计AAA的负担将随着最近的疗法而减少.
本系统性综述研究了炎症性关节疾病 (IJD) 中的AAA.

研究的目的:

系统地审查IAD中AAA的发病率,流行率,死亡率和治疗反应.
评估AAA随着时间的推移和疗法的影响的趋势.

主要方法:

在2024年10月之前对MEDLINE,EMBASE和Cochrane图书馆数据库进行系统审查.
在IJD中包括具有组织学AAA的前性/后性队列和病例系列 (≥10名患者).
对33项选定的研究进行了分析,指出了大量的异质性和大多数在2010年之前发表的研究.

主要成果:

近几十年来,AAA发病率和死亡率没有明显的趋势.
在类风湿性关节炎 (RA) 中AAA患病率显著下降,从2010年之前的16.7-25.2%降至2010年后的0.7%.
在结性脊柱炎 (AS) 中的AAA患病率下降,从2010年之前的6.1-8.5%降至2010年后的1.1-1.3%.
生物疗法在降低AAA患病率和改善GFR和血清粉样蛋白A等生物标志物方面发挥了积极作用.

结论:

最近的疗法,特别是生物药物,似乎正在减少IJD的AAA患病率.
更近期的,基于人口的流行病学数据是必要的,以充分了解目前的IAD相关AAA的负担.

关键词:

在AA氨基粉症症中.结性脊柱炎是一种疾病.炎症性关节疾病炎症性关节疾病青少年无形性关节炎 (Juvenile idiopathic arthritis) 是一种不良的疾病.牛皮关节炎牛皮关节炎类风湿性关节炎类风湿性关节炎类风湿性关节炎脊椎关节炎是一种脊柱性关节炎.

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