多代暴露于污染工业和发展障碍的多代暴露
Sara E Grineski1, Kevin Ramos2, Roger Renteria1
1University of Utah, Department of Sociology, 380 S. 1530 E., Rm. 301, Salt Lake City, UT 84112, USA.
The Science of the total environment
|June 14, 2025
概括
奶奶在怀孕期间暴露于环境污染可能会增加孙子的智力障碍 (ID) 风险. 这种祖先的暴露,特别是母亲的暴露,凸显了工业污染对儿童发育的潜在多代影响.
科学领域:
- 环境流行病学环境流行病学
- 生殖健康 生殖健康
- 发展性毒理学 发展性毒理学
背景情况:
- 动物研究表明,环境暴露会影响后代.
- 人类流行病学数据对多代环境暴露,特别是父母暴露的数据有限.
- 了解祖先对环境的影响对于公共卫生至关重要.
研究的目的:
- 调查祖先暴露于工业污染和后代智力障碍 (ID) 风险之间的关联 (F2).
- 检查多代影响,重点关注F0 (祖母) 怀孕期间的母亲和父亲的暴露.
- 评估污染设施的近距离和风险加权密度的影响.
主要方法:
- 利用一个独特的犹他州 (美国) 的数据集,其中包括6,380个后代 (F2).
- 地理编码历史工业设施位置和计算密度,距离祖母 (F0) 在与父母 (F1) 怀孕期间居住的3公里和5公里以内.
- 使用国家健康风险评分和分析与后代ID相关的权重设施密度.
主要成果:
- 在怀孕的母亲祖母 (F0) 附近设施的密度增加与后代 (F2) 患智障的几率更高有关.
- 靠近母方祖母的风险加权设施密度显示,与增加的ID几率有显著的关联.
- 与父亲祖母暴露的关联较弱,但存在,特别是在5公里处的风险加权密度.
结论:
- 祖先的环境暴露,特别是在怀孕期间来自母亲的血统,可能会增加下一代发展障碍的风险.
- 研究结果表明,工业污染对神经发育的潜在跨代影响.
- 强调在儿童发育的流行病学研究中考虑历史环境暴露的重要性.
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