人类中的新型和传统的基和多基物质:长期的时间变化和代谢干扰
Che-Jung Chang1, Anna S Young2, Alexander Keil3
1Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States; DLH LLC, Bethesda, MD, United States.
Environment international
|June 14, 2025
概括
新的和多基基物质 (PFAS) 比传统的PFAS显示出更大的时间变化和影响更广泛的代谢途径. 进一步的研究对于了解它们对健康的影响至关重要.
科学领域:
- 环境化学环境化学
- 代谢学 代谢学 代谢学
- 毒理学 毒理学 毒理学
背景情况:
- 传统的基和多基物质 (PFAS) 正被众多替代品所取代.
- 人们担心这些新兴的PFAS替代品对健康的潜在影响.
- 了解PFAS混合物的时间动态和代谢影响对于公共卫生至关重要.
研究的目的:
- 通过有针对性和非有针对性的方法,在原子尺度上评估血PFAS水平.
- 检查人类血中遗留和新型PFAS的时间变异性.
- 调查PFAS混合物与代谢中断之间的关联.
主要方法:
- 分析了来自200名参与者的400个血样本,这些样本是在两个时间点 (2007-2008年和2013-2014年) 收集的.
- 使用高分辨率质谱测量液体染色学检测PFAS.
- 采用网络分析,代谢组范围的关联研究和途径分析来评估代谢影响.
主要成果:
- 检测到24个遗留的PFAS和1,802个潜在的新型PFAS功能.
- 传统的PFAS表现出较低的时间变化,而新的PFAS表现出更大的变化.
- PFAS混合物与脂质,氨基酸,碳水化合物,辅因子和维生素以及内分泌代谢的破坏有关.
结论:
- 与传统化合物相比,新型PFAS表现出明显的时间变化.
- PFAS混合物,特别是含有新物质的混合物,与广泛的代谢变化有关.
- 进一步调查新型PFAS对健康的影响是有必要的.
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