高清超直流刺激 (HD-tDCS) 对精神分裂症患者的休息时大脑功能连接的影响持续的听觉语言幻觉
Rujuta Parlikar1, Harleen Chhabra1, Sowmya Selvaraj1
1Department of Psychiatry, National Institute of Mental Health And Neurosciences, Bengaluru, India.
Asian journal of psychiatry
|June 14, 2025
概括
高清透直流刺激 (HD-tDCS) 在精神分裂症患者具有听觉语言幻觉 (AVH) 中显著改变了大脑连接. 这种神经调节技术通过向关键大脑区域,显示出治疗持续性AVH的前景.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 听觉语言幻觉 (AVH) 是精神分裂症 (SZ) 的一个重要症状.
- 心理药物治疗对于持久性AVH通常是不够的.
- 高清透直流刺激 (HD-tDCS) 是一种新兴的神经调节技术.
研究的目的:
- 用fMRI研究HD-tDCS对SZ患者持续性AVH功能性大脑连接的神经效应.
- 为了检查HD-tDCS治疗后休息状态功能连接的变化.
主要方法:
- 一个双盲,随机,平行臂,假的受控研究.
- 34名持久性AVH的SZ患者接受了5天的每天两次的HD-tDCS会议.
- 使用3T扫描仪获取的静止状态fMRI数据.
主要成果:
- 与假装相比,主动HD-tDCS显著改变了静止状态的功能连接.
- 观察到的连接性变化是在Heschl的环状回路, temporoparietal接口,尾状核,先,侧皮皮和海马.
- 这些区域与SZ中AVH的病原发生有关.
结论:
- 在精神分裂症和听觉语言幻觉患者中,HD-tDCS诱导大脑连接的显著变化.
- 这些发现表明HD-tDCS调节了涉及AVH的神经回路.
- 这项研究为HD-tDCS在治疗AVH中的神经机制提供了新的fMRI证据.
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