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Updated: Jun 16, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
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成人HIV-1预防性单克隆抗体的固定剂量与基于体重的剂量:一项后期,跨协议的药理动力学建模研究

Yunda Huang1, Lily Zhang2, Huub Gelderblom2

  • 1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA.

EBioMedicine
|June 14, 2025
PubMed
概括

针对HIV-1广泛中和单克隆抗体 (mAbs) 的固定剂量策略提供了运行效率,同时保持了与基于体重的剂量相似的药理动力学. 这种方法可以改善HIV-1预防的不同体重的剂量一致性.

关键词:
剂量策略 剂量策略身体重量的指数.预防艾滋病毒 预防艾滋病毒人口药理动力学模型两个分区的分区.暴露中的变化性.

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