导致慢性乙型肝炎多神经病变的危险因素:一个横截面的视角
Nurbanu Sezak1, Ozge Eren Korkmaz2, Alper Doner3
1Izmir Demokrasi University Faculty of Medicine, Buca Seyfi Demirsoy Education and Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey.
概括
多神经病变 (PNP) 影响慢性乙型肝炎 (CHB) 患者,男性性别,高肝活动,晚年和HBeAg阳性是关键风险因素. 建议在CHB患者中提前对PNP进行查.
科学领域:
- 神经学 神经学
- 肝病学 肝病学是一种肝病学.
- 临床医学 临床医学
背景情况:
- 慢性乙型肝炎 (CHB) 是一个全球性的健康问题.
- 多神经病变 (PNP) 可能是CHB患者的并发症,表现为疼痛,麻醉和麻木等症状.
- 了解CHB中PNP的风险因素和患病率对于及时诊断和管理至关重要.
研究的目的:
- 在慢性乙型肝炎 (CHB) 患者中调查与多神经病 (PNP) 相关的危险因素.
- 在CHB患者中确定PNP的频率,这些患者出现了暗示神经损伤的症状.
- 区分轴突和脱髓化PNP亚型及其与疾病特征的相关性.
主要方法:
- 对350名CHB患者呈现PNP症状的回顾性分析.
- 从医院记录收集社会人口统计,与疾病相关的数据和神经传导研究 (NCS) 结果.
- 统计分析以确定CHB队列中PNP的独立风险因素.
主要成果:
- 在350名CHB患者中,59名 (16.9%) 诊断出PNP.
- 轴性PNP (72.9%) 比脱髓化PNP (27.1%) 更为普遍.
- PNP的独立风险因素包括高肝活动指数 (HAI) 评分,HBeAg阴性CHB,男性性别和晚年. 男性性别和严重的肝纤维化与轴突PNP有关,而较长的疾病持续时间与女性的脱髓化PNP有关.
结论:
- 男性性别,高HAI得分,晚年和HBeAg阳性是CHB患者PNP的重要危险因素.
- 患有严重肝纤维化的男性患者具有较高的轴突PNP风险.
- 患有长期CHB的女性患者更容易患上脱髓化PNP,这凸显了在CHB护理中需要进行例行PNP查的必要性.
相关概念视频
01:24Chronic Pancreatitis I: Introduction
84
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
84
01:29Biological Causes of Schizophrenia
51
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
51
01:29Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
525
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
525