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Updated: Jun 16, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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低温EM结构分析揭示了来自大脑的寡合体中多样化的多孔结构

Anvesh K R Dasari1, Nemil Bhatt2, Md Anzarul Haque2

  • 1Electron Microscopy Shared Resources, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.

Biochemical and biophysical research communications
|June 14, 2025
PubMed
概括

研究人员对阿尔茨海默氏症的陶寡合体进行了表征.

关键词:
这是一个ADRD.由大脑衍生出来的寡合体.化电磁波是一种冷电磁波.错误折叠 没有错误折叠类似毛孔的寡合体.塔乌·塔乌 (Tau Tau) 是一个

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Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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