解离性症状的模式在创伤后应激障碍和治疗耐药抑郁症的首次施用esketamine之间有所不同
David Williamson1, Linda Williamson2, Viola Vaccarino3
1Department of Psychiatry, University of South Alabama College of Medicine, United States of America; Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, United States of America.
Journal of affective disorders
|June 14, 2025
概括
在接受esketamine的创伤后应激障碍 (PTSD) 和耐治疗抑郁症 (TRD) 患者之间,分离性症状有所不同. 创伤后应激障碍患者报告了更多的分离性失忆症和身份碎片化,而TRD患者报告了更多的非个性化和非现实化.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 分离性症状在创伤后应激障碍 (PTSD) 中很常见.
- 在治疗耐药抑郁症 (TRD) 的初始乙胺 (ESK) 治疗期间也会出现分离性症状.
- 了解这些差异对于患者护理至关重要.
研究的目的:
- 为了比较PTSD患者中解离性症状的患病率和模式,与接受esketamine的TRD患者相比.
- 为了确定区分这两个患者群体的特定分离性症状领域.
主要方法:
- 分析了134名患有各种创伤暴露的PTSD患者的数据.
- 分析了759名TRD患者的数据,这些患者接受了他们的第一个埃斯基坦胺治疗.
- 报告的分离性症状的比较,包括非个性化,非现实化,分离性失忆症和身份分裂.
主要成果:
- 整体分离性症状在乙胺 (ESK) 组 (TRD患者) 中更为普遍.
- 与TRD患者相比,PTSD患者报告的分离性失忆症和身份碎片化显著增加.
- 脱人格化和脱现是TRD组中最常见的症状,而分离性失忆症在PTSD组中最常见.
结论:
- 解离性症状的模式在PTSD和TRD患者之间显著不同,这些患者接受了埃斯基坦胺治疗.
- 这些差异表明,在不同的临床背景下,分离性症状的潜在原因可能是不同的.
- 需要进一步的研究来探讨胺剂量和持续时间的影响.
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