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转基因-CSF在乳腺癌中的双重作用:免疫调节和治疗影响

Yuxuan Guo¹, Yingya Hu¹, Da Huang²

¹Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University Health Science Center, Changsha 410013, China; Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Changsha 410013, China.

Critical reviews in oncology/hematology

|June 14, 2025

概括

颗粒细胞-巨细胞殖民地刺激因子 (GM-CSF) 在乳腺癌中具有双重作用,影响瘤微环境. 这篇评论探讨了GM-CSF.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

颗粒细胞-巨细胞殖民地刺激因子 (GM-CSF) 是一个关键的造血生长因子,影响免疫细胞功能.
乳腺癌的发病包括一个复杂的瘤微环境 (TME),其中GM-CSF发挥着多方面的作用.
TME包括瘤细胞,免疫细胞和树皮细胞,GM-CSF充当细胞间通信的关键调解者.

研究的目的:

系统地审查GM-CSF在乳腺癌进展中的调控作用.
探索GM-CSF在乳腺癌治疗策略中的治疗潜力.
为未来的研究和GM-CSF的临床应用提供见解.

主要方法:

关于GM-CSF在乳腺癌中的结构和生物功能的文献综述.
对GM-CSF在瘤微环境中的双重作用的分析.
检查涉及GM-CSF的治疗策略,包括疫苗和输送系统.

主要成果:

在TME中,GM-CSF表现出双重作用,既具有抗瘤免疫效应,也具有潜在的前瘤活动.
转基因-CSF可以激活免疫细胞,增强抗原呈现,并提高疫苗的疗效.
相反,GM-CSF可能会促进免疫抑制细胞,如与瘤相关的巨细胞和髓状细胞衍生的抑制细胞.

结论:

在乳腺癌中GM-CSF的复杂功能需要仔细考虑治疗开发.
疫苗开发,组合疗法和纳米粒子输送等策略表明,利用GM-CSF的抗瘤潜力是有希望的.
进一步研究GM-CSF在TME中的机制对于优化其在乳腺癌治疗中的临床应用至关重要.

关键词:

乳腺癌是什么? 乳腺癌是什么双重的角色双重的角色颗粒细胞-巨细胞殖民地刺激因子.免疫治疗是一种免疫疗法.瘤微环境是一个微环境.

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