母亲运动和新生儿过度养会导致子女的性别特异的外周和大脑变化
Pauline Maciel August1, Bernardo Gindri Dos Santos2, Ismael Mesquita2
1Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Brain research
|June 14, 2025
概括
母亲运动可以减轻新生儿过度养对幼发育的一些负面影响,包括减少体脂和血糖. 然而,它无法防止雄性幼海马体中线粒体功能受损.
科学领域:
- 发育生物学是发展生物学.
- 代谢健康 代谢健康
- 神经科学是一个神经科学.
背景情况:
- 儿童肥胖是一个日益关注的问题,其终身健康影响越来越大.
- 健康和疾病的发育起源 (DOHaD) 概念强调了早期对成人健康的影响.
- 产前因素会影响代谢健康,增加慢性疾病的风险.
研究的目的:
- 调查产前运动和新生儿过度养对幼犬发育的影响.
- 评估外周代谢参数,下丘脑和海马线粒体功能以及氧化应激.
- 评估母亲运动和过度养对后代健康结果的相互作用.
主要方法:
- 在怀孕期间,雌性Wistar大鼠被分配到久坐或游泳运动组.
- 新生儿子大小被调整以诱导小狗的控制或过度养条件.
- 分析了幼的发育,代谢参数和特定大脑区域的线粒体功能.
主要成果:
- 孕产妇的运动减少了雌性幼的过度养引起的中肠脂肪.
- 孕产妇运动可以防止过度养的雄性幼血糖升高.
- 在过度养环境中炼的雄性幼表现出海马线粒体功能受损.
- 在遭受母体运动和/或过度养的幼中观察到眼睛加速开放.
结论:
- 孕产妇的运动显示出对新生儿过度养的一些有害影响的保护作用,例如增加脂肪和血糖.
- 孕产妇运动的好处可能是性别特异的,尽管孕产妇运动,但雄性幼显示出海马线粒体功能受损.
- 这些发现强调了产前干预对于减轻与早期代谢障碍相关的风险的重要性.
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