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Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity
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描述 7,8-二-8-oxoadenine 的切割过程,由提氨酸DNA糖解酶进行

Hardler W Servius1, Alexander C Drohat2

  • 1Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

The Journal of biological chemistry
|June 14, 2025
PubMed
概括

胺DNA糖酶 (TDG) 能有效地去除突变性7,8-二-8-oxoadenine (oxoA) 的DNA损伤. 在这种修复过程中,TDG中特定的氨基酸残留对DNA修复机制的信息至关重要.

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