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六价暴露工人的氧化损伤,遗传和表观遗传变化 - 在SafeChrom项目中进行的横截面研究

Zheshun Jiang¹, Agneta Runkel¹, Christian Lindh¹

¹Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.

Environmental research

|June 14, 2025

概括

在工人中,低至中度的六价 (Cr(VI)) 暴露与增加的氧化应激,更长的端粒和表观遗传变化有关,所有这些都与肺癌风险有关. 这些发现强调需要减少Cr (VI) 暴露.

科学领域:

职业健康职业健康职业健康
环境毒理学环境毒理学
分子流行病学分子流行病学

背景情况:

六价 (Cr(VI)) 是一个已知的肺癌原体.
低至中度Cr (VI) 职业暴露的基因毒性和致变性影响尚不清楚.
这项研究调查了Cr(VI) 暴露与氧化损伤和遗传/表观遗传变化的相关性.

研究的目的:

评估职业Cr (VI) 暴露与氧化损伤,遗传损伤和表观遗传变化的生物标志物之间的关系.
为了评估低至中度Cr (VI) 暴露对工人的分子影响.
为减少Cr (VI) 暴露风险的策略提供信息.

主要方法:

研究了113名暴露于Cr(VI) 的工人和72个对照组.
测量的生物标志物包括尿中的8-基-2'-脱氧氨酸 (8-OHdG),微核 (MNRET),线粒体DNA复制数 (mtDNA-cn),端粒长度 (TL) 和DNA甲基化.
在粉尘,尿液 (U-Cr) 和红细胞 (RBC-Cr) 中测量了Cr (VI) 和总水平.

主要成果:

与对照组相比,暴露的工人具有更高的8-OHdG,TL和MGMT促进物甲基化,以及较低的mtDNA-cn和MNRET.
在TL和U-Cr之间,以及在8-OHdG/MGMT甲基化和RBC-Cr之间观察到正相关性.
多变量分析证实了暴露个体中更高的8-OHdG,TL和MGMT促进物甲基化.

结论:

低至中度Cr (VI) 暴露与氧化应激增加,端粒延长和表观遗传变化有关.
这些分子变化以前与肺癌风险有关.
这些发现突显了Cr (VI) 的分子影响以及减少暴露的重要性.

关键词:

生物监测生物监测影响生物标志物六价的六价是一种职业暴露职业暴露有毒性有毒性

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