相关实验视频

Updated: Jun 16, 2025

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

解读泌尿癌中的分子通路:通往精密治疗的门户

Kiavash Hushmandi¹, Najma Farahani², Behzad Einollahi¹

¹Nephrology and Urology Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Journal of advanced research

|June 14, 2025

概括

针对性疗法在泌尿癌中表现有前途,通过抑制PI3K/Akt和mTOR等关键信号通路. 进一步的研究可以提高治疗疗效和患者存活率.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

泌尿系统癌症,包括前列腺癌,癌和膀癌,存在重大挑战,特别是在转移阶段.
虽然手术至关重要,但化疗,免疫疗法和向疗法的进步正在改善患者的治疗结果.

研究的目的:

本综述探讨了泌尿癌的向治疗方法.
它专注于像PI3K/Akt,mTOR,c-Met/HGF,PD-1/PD-L1这样的信号通路,以及瘤进展和抵抗中的类固醇激素受体.

主要方法:

对针对性疗法和尿道癌症信号通路的当前文献的审查.
分析特定途径 (PI3K/Akt,mTOR等) 的作用. 在瘤形成和治疗耐药性方面.

主要成果:

对PI3K/Akt和mTOR通路的调节失调有助于癌症生长和治疗耐药性.
氨酸激酶抑制剂和免疫检查点抑制剂显示出有效性,但面临着耐药性和毒性等挑战.

结论:

了解信号通路对于开发有效的向治疗至关重要.
将途径研究与临床实践相结合,可以提高泌尿癌的治疗疗效和患者存活率.

关键词:

基于生物标志物驱动的治疗精确瘤学是一门精确的专业.有针对性的治疗.治疗性耐药性是一种治疗性耐药性.泌尿器科的新生病.

更多相关视频

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...