免疫媒介炎症疾病患者心肌纤维化决定因素
Nicholas Black1,2, Joshua Bradley1,2, Fardad Soltani1,2
1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Advances in rheumatology (London, England)
|June 14, 2025
概括
系统性硬化症 (SSc) 与免疫媒介性炎症性疾病 (IMIDs) 中心肌纤维化较大有关. 吸烟和体重指数 (BMI) 也影响纤维化,较低的BMI与风险增加有关.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 心肌纤维化是不良结果的关键预测因素.
- 免疫媒介性炎症性疾病 (IMIDs) 中心肌纤维化决定因素尚不清楚.
研究的目的:
- 在IMID患者中确定影响心肌纤维化因素.
- 用心血管磁共振 (CMR) 来测量心肌纤维化细胞外体积 (ECV).
主要方法:
- 对116名IMID患者进行了一项横截面研究.
- 心血管磁共振 (CMR) T1映射测量了心肌心电流.
- 单变量和多变量线性回归分析了ECV的决定因素.
主要成果:
- 在IMID诊断中,ECV显著变化,系统性硬化症 (SSc) 的水平更高.
- 高ECV的独立预测因素是SSc诊断,吸烟和较低的身体质量指数 (BMI).
- 低血压,吸烟和BMI解释了大约26.5%的ECV变化.
结论:
- 系统性硬化症 (SSc) 与其他IMID相比,与心肌纤维化增加有关.
- 在IMID患者中,心肌纤维化是由SSc,吸烟和BMI独立决定的.
- 结果可能不适用于所有IMID患者,因为研究队列由于临床原因接受了CMR.
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