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小鼠的后岛皮质编码了求爱声调的表达和接受方面
Thomas Pomberger1, Katherine S Kaplan1, Rene Carter1
1Department of Neurobiology, Duke University, Durham, NC 27710, USA.
Cell reports
|June 15, 2025
概括
在小鼠体内,后侧胰岛 (pIns) 编码了声音表达和声音接收. 在发声和声音处理过程中,pIns中的不同神经元群体是活跃的,受社会环境的影响.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 审计处理 审计处理
背景情况:
- 社会上有效的语音沟通依赖于大脑区域处理语音表达和接收.
- 这些过程是由社会背景调节的,需要专门的神经机制.
研究的目的:
- 为了研究后面岛屿 (pIns) 在编码声表达和接收中的作用.
- 为了确定在语音沟通期间,pIns活动是否受到社会背景的调制.
主要方法:
- 在社交互动小鼠中利用了一种新的行为分析和微内镜成像.
- 在发声表达和接收过程中记录了pIns中的神经元活动 (感兴趣的区域 (ROI)).
- 进行追踪实验以确定神经电路连接.
主要成果:
- 在发声表达与接收期间活跃的pInsROI的大部分分别为不同的子集.
- 观察到在发声之前增加了pIns活动,表明了运动信号,即使在先天聋的小鼠中也是如此.
- 证明受体pIns活动受到社会背景的强烈调节.
- 揭示了深层pIns神经元与听觉丘脑和中脑声门区域的直接联系.
结论:
- 后面的岛屿 (pIns) 是声音沟通的关键大脑区域.
- pIns神经元编码了发声的产生 (表达) 和感知 (接收).
- 社会背景显著地影响了神经系统在脑内对发声的处理.
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