丸激素对跨性别男性血液凝固标志物的作用
Estella Thaisa Sontag Dos Reis1, Carla Maria Franco Dias1, Carolina Sales Vieira1
1Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
Hematology, transfusion and cell therapy
|June 15, 2025
概括
在跨性别男性中,用丸激素进行性别确认激素治疗显示体重,BMI,血红蛋白和血红素的增加,HDL胆固醇和第七因子的降低,所有这些都在正常范围内. 需要进一步的长期研究来评估血栓栓塞的风险.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 跨性别者健康 跨性别者健康
背景情况:
- 跨性别男性的性别肯定激素治疗 (GAHT) 通常涉及丸激素,但其对血液凝固风险的影响尚未完全理解.
- 关于与跨性别男性使用丸激素相关的静脉血栓栓塞 (VTE) 风险的研究有限.
研究的目的:
- 为了研究肌肉内氨酸对跨性别男性特定血液凝固标志物的影响.
- 在开始丸激素治疗后,评估直接和间接凝血标志物的变化.
主要方法:
- 一项前性观察性研究跟踪了跨性别男性开始肌肉内测试酸 (Depo-Testosterone).
- 血液凝固标志物包括前血栓时间,激活的部分血栓塑时间,d-二次体,抗血栓和因子VII和VIII在治疗开始前和12周后被测量.
主要成果:
- 19名跨性别男性 (平均年龄为23.7岁) 被录取. 12周后,体重,BMI,血清丸激素,血红蛋白和血红素显著增加.
- 检测到高密度脂蛋白 (HDL) 胆固醇和因子VII水平的显著下降.
- 尽管发生了重大变化,但所有测量变量都保持在正常参考范围内.
结论:
- 跨性别男性的肌肉内丸激素治疗与血红素,血红蛋白,BMI,HDL胆固醇和第七因子的显著变化有关.
- 这些观察到的变化保持在正常的生理界限内.
- 长期后续研究对于全面了解GAHT患者群体中VTE和动脉血栓栓塞风险至关重要.
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