在威尔逊病中,铜的物种化和总的基本微量元素含量
Aleksandar Stojsavljević1, Katarina Kozlica2, Ivana Šarac3
1Innovation Center, Faculty of Chemistry, University of Belgrade, Belgrade, Serbia.
Journal of pharmaceutical and biomedical analysis
|June 15, 2025
概括
威尔逊病 (WD) 患者的基本微量元素水平发生变化,特别是铜,和. 长期治疗对这些元素和铜物种产生影响,这表明疾病监测的潜在生物标志物.
科学领域:
- 生物化学 生物化学
- 医学遗传学 医学遗传学
- 临床化学 临床化学
背景情况:
- 威尔逊病 (WD) 是一种罕见的遗传疾病,影响铜代谢.
- 铜平衡受损导致器官中有毒物质的积累.
研究的目的:
- 为了比较WD患者和对照者的血和尿液中的微量元素含量.
- 分析血中的铜 (Cu) 变异并评估治疗影响.
主要方法:
- 感应合等离子体质谱 (ICP-MS) 用于总元素分析.
- 高性能液体染色学与ICP-MS (HPLC-ICP-MS) 结合,用于Cu特异 (Cu-,Cu-人血清白蛋白,Cu-低分子量).
主要成果:
- 与对照组相比,WD患者表现出较低的血Cu,较高的血Zn和Se.
- 尿液分析显示,WD患者的Cu和Zn含量较高,Se,Cobalt (Co) 和Molybdenum (Mo) 含量较低.
- 治疗影响了 Zn,Se 和 Cu 水平;长期治疗改变了 Cu-HSA 和 Cu-LMM 分数.
结论:
- 在WD患者中,基本微量元素的概况有显著差异.
- 药物治疗改变了微量元素的含量和Cu的特异性.
- 改变的Cu-HSA和Cu-LMM分数可以作为WD的潜在血生物标志物.
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