水平升高是儿科神经神经传感听力损失的危险因素
Neil Rana1, Chelsea Cleveland2, Daniel Karasik2
1Case Western Reserve University School of Medicine, Cleveland, OH, USA.
International journal of pediatric otorhinolaryngology
|June 15, 2025
概括
儿童暴露与感官神经神经听力损失的更高风险有关. 即使在儿童血液中含量很低也可能会损害听力,因此需要临床意识和听力学转诊.
科学领域:
- 环境健康 环境健康
- 儿科健康 儿科健康
- 听力学 听力学是指听力学.
背景情况:
- 尽管1978年美国禁止使用涂料,儿童暴露仍然存在.
- 疾病预防控制中心 (CDC) 2021年血水平的参考值为3.5μg/dL,因为即使是低水平也是有害的.
- 儿科暴露的神经效应已知,但与听力损失的联系研究较少.
研究的目的:
- 调查儿科暴露与神经感官听力损失 (SNHL) 之间的关联.
主要方法:
- 利用Trinetx分析网络,查询超过7800万患者的非身份电子健康记录.
- 确定了血含量≥3.5μg/dL的儿科患者 (≤18岁) 和一个对照组 (<3.5μg/dL).
- 排除了患有先天性细胞大脑病毒,内耳形或噪音引起的听力损失的参与者.
主要成果:
- 血水平升高 (≥3.5μg/dL) 的儿童,SNHL诊断率为2.83%.
- 对照组 (没有升高的含量) 的SNHL诊断率为2.32%.
- 水平升高与SNHL的1.22相对风险相关 (95% CI:1.21-1.23,p=0.005).
结论:
- 血含量≥3.5μg/dL的儿科患者患SNHL的可能性是1.22倍.
- 这项研究是使用CDC目前的参考值来检查暴露和SNHL的最大研究.
- 临床医生应考虑这一关联,并将儿童转诊听力学评估.
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